I got the urge to play modded again. So I joined Colossalcraft about two weeks prior to the thing closing down. Bummer.
So anyway found another server.
So what's changed...
Tinkers construct seems to go on as always, except that a 1-block smeltery works. Its a bit rubbish though unless you use it to melt compressed cobble (that works to double comp.) and make more blocks to enlarge it.
Item equivalence seems to have been nerfed a bit, it seems as if you can't use Big Reactors to make RTG fuel any more, if you want unending EU you'll need to go the full IC2 nuclear route.
The IC2 coolant recipies still aren't in NEI but they are in the F/S canning machine's list.
The MFR laser drill will return iridium ore blocks, but that is less useful than it sounds as you can't turn it into IC2 iridium.
The Thermal Dyn. Viaduct looks fun. Too expensive to replace rails but a great way to get around a big base.
The map I'm playing reminds me of our Tekkit map with the amount of underground lava I'm finding.
Enderpearls seemed hard to get but there is an "end" warp.